The European Chemicals Agency has contracted the Fraunhofer Institute to explore one potential alternative method to current aquatic toxicity testing of chemicals involving the use of fish.

The project examines whether the Fish Embryo Toxicity (FET) test, one of the most popular alternatives to acute toxicity testing, could be considered as a valid alternative to chronic fish toxicity testing when enhanced with transcriptomics measurements.

In ecotoxicological assessment, fish are used to evaluate short and long-term toxicity of chemicals in the aquatic environment. In addition, fish are important models for evaluating modes of toxicological action such as endocrine-disrupting effects in the environment.

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